Key result
Constant work rate cycle exercise parameters show high test-retest repeatability in COPD patients.
Why the study?
The distribution profiles and repeatability of key exercise performance parameters during cycle ergometry in multicentre COPD trials were not well characterized.
Are ventilatory and perceptual parameters reliably measured during constant work rate cycle exercise in multicentre trials of COPD?
Population
463 subjects with COPD, mean FEV1 43+/-13% predicted
Comparison
Test-retest comparison across two run-in visits
Design
Multicentre observational study with repeated measures
Authors
Loading...
May inform endpoint selection in multicentre COPD trials; leaves open routine clinical adoption pending validation.
Observational (n=463)
Yes
Are ventilatory and perceptual parameters reliably measured during constant work rate cycle exercise in multicentre trials of COPD?
Key perceptual and ventilatory parameters can be reliably measured during constant work rate cycle exercise in multicentre clinical trials for COPD.
O’Donnell et al. (2009) conducted an observational in chronic obstructive pulmonary disease (COPD) (n=463). Constant work rate (CWR) cycle tests at 75% of maximum work capacity was evaluated on Test-retest repeatability of measurements of endurance time (ET), inspiratory capacity (IC), ventilation and dyspnoea intensity during exercise. Constant work rate cycle exercise parameters, including inspiratory capacity (R ≥ 0.87) and ventilation (R ≥ 0.92), showed high test-retest repeatability in multicentre trials of COPD patients.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: