Key result
Long-term diltiazem reduces blood pressure, ventricular weight, and plasma ANP in spontaneously hypertensive rats.
Why the study?
The effect of long-term diltiazem treatment on plasma and atrial concentrations of atrial natriuretic peptides in spontaneously hypertensive rats was examined to understand its impact on cardiac overload.
Does long-term treatment with diltiazem affect atrial natriuretic peptide concentrations in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats and Wistar-Kyoto rats
Comparison
Long-term diltiazem treatment vs untreated
Design
Preclinical experimental study
Follow-up
Long-term
Authors
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Hypothesis-generating in hypertensive rat models; leaves open translation to human ANP modulation or therapy.
Does long-term treatment with diltiazem affect atrial natriuretic peptide concentrations in spontaneously hypertensive rats?
Long-term diltiazem treatment in spontaneously hypertensive rats reduces blood pressure and cardiac hypertrophy, which correlates with a normalization of plasma and atrial ANP levels.
Kohno et al. (1988) studied Hypertension. Diltiazem vs. Untreated SHR and WKY was evaluated on Plasma and atrial concentrations of atrial natriuretic peptides (ANP). Long-term diltiazem treatment in spontaneously hypertensive rats reduced blood pressure, ventricular weight, and plasma ANP concentrations while increasing left atrial ANP concentrations.
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