Key result
Moderate to high malnutrition risk linked to ~437% higher mortality and repeat PCI in NSTEMI.
Why the study?
The relationship between malnutrition and follow-up cardiovascular events in patients with NSTEMI was unclear.
Does malnutrition assessed by the Geriatric Nutritional Risk Index predict recurrent cardiovascular events and mortality in patients with NSTEMI?
Cohort (n=298)
Does malnutrition assessed by the Geriatric Nutritional Risk Index predict recurrent cardiovascular events and mortality in patients with NSTEMI?
Hazard Ratio: 5.372
p-value: p=<0.001
The Geriatric Nutritional Risk Index is a significant predictor of repeat PCI and all-cause mortality in patients with NSTEMI.
Supports GNRI screening for risk stratification in NSTEMI; leaves open whether nutritional interventions improve outcomes in prospective trials.
Aim To investigate the relationship between malnutrition and follow-up cardiovascular (CV) events in non-ST-segment elevation myocardial infarction (NSTEMI).Material and methods A retrospective study was performed on 298 patients with NSTEMI. The baseline geriatric nutritionalrisk index (GNRI) was calculated at the first visit. The patients were divided into three groups accordingto the GNRI: >98, no-risk; 92 to ≤98, low risk; 82 to <92, moderate to high (MTH) risk. The studyendpoint was a composite of follow-up CV events, including all-cause mortality, non-valvular atrialfibrillation (NVAF), hospitalizations, and need for repeat percutaneous coronary intervention (PCI).Results Follow-up data showed that MTH risk group had significantly higher incidence of repeat PCI and all-cause mortality compared to other groups (p<0.001). However, follow-up hospitalizations and NVAFwere similar between groups (p>0.05). The mean GNRI was 84.6 in patients needing repeat PCI and99.8 in patients who did not require repeat PCI (p<0.001). Kaplan Meier survival analysis showed thatpatients with MTH risk had significantly poorer survival (p<0.001). According to multivariate Coxregression analysis, theMTH risk group (hazard ratio=5.372) was associated with increased mortality.Conclusion GNRI value may have a potential role for the prediction of repeat PCI in patients with NSTEMI.
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Kaplan et al. (2021) conducted a cohort in non-ST-segment elevation myocardial infarction (NSTEMI) (n=298). Moderate to high malnutrition risk (GNRI 82 to <92) vs. No-risk (GNRI >98) and low-risk (GNRI 92 to ≤98) groups was evaluated on Composite of follow-up CV events, including all-cause mortality, non-valvular atrial fibrillation (NVAF), hospitalizations, and need for repeat percutaneous coronary intervention (PCI) (HR 5.372, p=<0.001). Moderate to high malnutrition risk (GNRI 82 to <92) was associated with increased mortality (HR 5.372) and a significantly higher incidence of repeat PCI in patients with NSTEMI.
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