Key result
Hemoglobin below 10.7 g/dL predicts higher mortality and HF rehospitalization in HFpEF with mild CKD.
Why the study?
The impact of anemia on prognosis in HFpEF patients with CKD, particularly by CKD severity, was entirely unknown.
Does anemia worsen prognosis in patients with heart failure with preserved ejection fraction and chronic kidney disease?
Population
HFpEF patients with CKD including mild and moderate to severe stages
Comparison
Anemic patients vs non-anemic patients
Design
Cohort study
Authors
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Anemia may flag higher-risk HFpEF patients with mild CKD for monitoring; leaves open whether correction alters outcomes.
Cohort
Does anemia worsen prognosis in patients with heart failure with preserved ejection fraction and chronic kidney disease?
Anemia is an independent predictor of mortality and heart failure rehospitalization specifically in HFpEF patients with mild CKD, highlighting a specific subgroup where anemia impacts prognosis.
Okuno et al. (2021) conducted a cohort in Heart failure with preserved ejection fraction and chronic kidney disease. Anemia vs. Non-anemic patients was evaluated on All-cause mortality and heart failure rehospitalization. Anemia was an independent predictor of all-cause mortality and heart failure rehospitalization in HFpEF patients with mild CKD, with an optimal prognostic hemoglobin threshold of 10.7 g/dL.
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