Key result
Etanercept or adiponectin attenuates posttraumatic ischemic myocardial injury by countering TNF-α-induced adiponectin downregulation.
Why the study?
Nonlethal mechanical trauma significantly increases myocardial infarction risk despite normal coronary arteries, but the molecular mechanisms exacerbating ischemic myocardial injury are unclear, particularly the roles of tumor necrosis factor α and adiponectin.
Does etanercept or exogenous adiponectin supplementation reduce posttraumatic myocardial ischemia/reperfusion injury in mice?
Does etanercept or exogenous adiponectin supplementation reduce posttraumatic myocardial ischemia/reperfusion injury in mice?
Tumor necrosis factor α-induced downregulation of adiponectin exacerbates posttraumatic ischemic myocardial injury, suggesting that blocking TNF-α or restoring adiponectin may have prophylactic value.
Answers are grounded in this paper and cite their sources.
Supports TNF-α/adiponectin targeting in murine posttraumatic MI; hypothesis-generating, human studies needed before clinical consideration.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2011) studied Posttraumatic myocardial ischemia/reperfusion injury. Etanercept and exogenous adiponectin supplementation was evaluated on Ischemic myocardial injury (apoptosis, infarct size, cardiac function). Tumor necrosis factor α-induced downregulation of adiponectin exacerbates posttraumatic ischemic myocardial injury, which can be attenuated by etanercept or adiponectin supplementation.
Synapse has enriched 10 related papers. Consider them for comparative context: