Key result
Angiotensin II triggers a pressor response and increases catecholamines in nonmammalian vertebrates, blocked by phentolamine.
Why the study?
The interaction between angiotensin II and catecholamines in nonmammalian vertebrates and its evolutionary significance was examined.
Angiotensin II-induced catecholamine release is a phylogenetically ancient mechanism that mediates pressor responses in lower vertebrates.
Supports ancient Ang II-catecholamine signaling; hypothesis-generating for mammalian cardiovascular regulation and leaves open clinical translation.
The interaction between angiotensin II (ANG II) and catecholamines was examined in nonmammalian vertebrates. ANG II challenge caused a significant pressor response in representatives of the seven vertebrate classes. Additionally, plasma levels of both epinephrine and norepinephrine increased following intravascular ANG II injection in the conscious lumpfish, bullfrog, and turtle, and the anesthetized chicken. Phentolamine pretreatment totally abolished ANG II pressor action in the hagfish and chicken and diminished the ANG II pressor response in other classes of vertebrates. The ability of ANG II to release catecholamines appears to be a phylogenetically ancient interaction and indicates that catecholamines may play an important role in the physiological expression of ANG II action in lower vertebrates.
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Carroll et al. (1982) studied this question. Angiotensin II (ANG II) was evaluated on Pressor response and plasma levels of epinephrine and norepinephrine. Angiotensin II challenge caused a significant pressor response and increased plasma catecholamines in nonmammalian vertebrates, an effect abolished or diminished by phentolamine pretreatment.
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