What does this research mean for the field?

Inducible nitric-oxide synthase undergoes auto-nitrosation to form specific N-NO-pterin and S-NO-Cys modifications that regulate enzyme stability and nitric oxide production. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 22, 2010Journal of Biological ChemistryOpen Access

Nitric-oxide Synthase Forms N-NO-pterin and S-NO-Cys

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Key result

Specific N-NO-pterin and S-NO-Cys modifications in iNOS may help control NO production.

Authors

RRR.J. RosenfeldScripps Research Institute JBJoseph BonaventuraUniversity of Essex BSBlair R. SzymczynaBoston University

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Implication

May inform iNOS regulation under nitrosative stress; leaves open cardiovascular translation.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Rosenfeld et al. (2010) studied this question. Structural and biochemical analysis of inducible nitric-oxide synthase revealed specific N-NO-pterin and S-NO-Cys modifications that may help control nitric oxide production.

synapsesocial.com/papers/6aade12654c33b521da35514 https://doi.org/10.1074/jbc.m109.072496

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Nitric-oxide Synthase Forms N-NO-pterin and S-NO-Cys

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Key Points

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Nitric-oxide Synthase Forms N-NO-pterin and S-NO-Cys

Discussion

Member takes

Implication

Key Points

Cite This Study

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