Key result
Normotensive first-degree relatives of hypertensives show higher initial platelet noradrenaline efflux versus no family history.
Why the study?
The relationship between noradrenaline efflux from platelets and essential hypertension, including familial predisposition, was not well characterized.
Cross-Sectional (n=63)
Answers are grounded in this paper and cite their sources.
The rate of noradrenaline efflux from platelets correlates with diastolic blood pressure and is elevated in normotensive relatives of hypertensive patients, suggesting a potential genetic marker or mechanism for essential hypertension.
The rate (k) of initial efflux of noradrenaline from platelets was determined in 63 individuals. A highly significant correlation was found between diastolic blood pressure and efflux rate. 2. When platelets are incubated in buffers with various Na+ concentrations in the range 110-170 mmol/l a higher Na+ concentration will give a faster efflux of noradrenaline for each concentration tested. 3. The value for k was determined in 41 normotensive first-degree relatives of hypertensive individuals and 21 persons with no family history of hypertension. Efflux rate of noradrenaline was significantly higher in the relatives and within this group was a subgroup with very high k values.
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Mattiasson et al. (1979) conducted a cross-sectional in Essential Hypertension (n=63). Family history of hypertension vs. No family history of hypertension was evaluated on Rate of initial efflux of noradrenaline from platelets. Normotensive first-degree relatives of hypertensive individuals had a significantly higher initial efflux rate of noradrenaline from platelets compared to persons with no family history.
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