Key result
Early post-STEMI NYHA class ≥2 is linked to ~278% higher 1-year death or HF hospitalization risk.
Why the study?
Does early post-discharge heart failure (NYHA class ≥2) increase the risk of death or hospitalization for heart failure in STEMI patients treated with primary PCI?
Population
402 patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary…
Comparison
New York Heart Association functional class ≥2… vs New York Heart Association functional class 1 at…
Design
Cohort
Follow-up
1-year
Authors
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Early post-discharge NYHA ≥2 symptoms flag high-risk STEMI patients after PCI; hypothesis-generating for targeted intervention trials.
Cohort (n=402)
Does early post-discharge heart failure (NYHA class ≥2) increase the risk of death or hospitalization for heart failure in STEMI patients treated with primary PCI?
Hazard Ratio: 3.78 (95% CI 1.16–12.22)
Absolute Event Rate: 11.8% vs 2.8%
p-value: p=0.03
Early post-discharge heart failure symptoms (NYHA class ≥2) identify a high-risk cohort for subsequent death or heart failure hospitalization in STEMI patients treated with primary PCI, independent of infarct size.
Giustino et al. (2017) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) (n=402). NYHA class ≥2 at 30 days vs. NYHA class 1 at 30 days was evaluated on death or hospitalization for heart failure (HR 3.78, 95% CI 1.16-12.22, p=0.03). Early post-discharge heart failure symptoms (NYHA class ≥2) after STEMI were associated with a higher 1-year risk of death or heart failure hospitalization (11.8% vs 2.8%; HR 3.78; P=0.03).