Key result
Two or more hospitalizations linked to ~127% higher post-discharge mortality in chronic hemodialysis patients.
Why the study?
Hemodialysis patients are at high risk of hospitalization and their condition may worsen with repeated hospitalization, but the impact of cumulative hospitalizations on post-discharge mortality was unclear.
Does a higher cumulative number of hospitalizations increase post-discharge mortality in chronic hemodialysis patients?
Population
3,359 adult hemodialysis patients in Japan from DOPPS phases 3 and 4
Comparison
Higher cumulative number of hospitalizations vs fewer or no hospitalizations
Design
Prospective cohort study
Follow-up
Median 2.7 years
Authors
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May flag high-risk hemodialysis patients for closer monitoring; hypothesis-generating for interventions reducing readmissions.
Cohort (n=3,359)
Yes
Does a higher cumulative number of hospitalizations increase post-discharge mortality in chronic hemodialysis patients?
Hazard Ratio: 2.27 (95% CI 1.59–3.23)
A higher cumulative number of hospitalizations is associated with a dose-dependent increase in post-discharge mortality among chronic hemodialysis patients.
Shimizu et al. (2018) conducted a cohort in Chronic hemodialysis (n=3,359). Cumulative number of hospitalizations vs. No hospitalizations was evaluated on All-cause mortality after discharge (HR 2.27, 95% CI 1.59-3.23). Experiencing two or more hospitalizations was associated with increased post-discharge mortality in chronic hemodialysis patients compared to no hospitalizations (HR 2.27; 95% CI 1.59-3.23).
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