Key result
Pharmacologic vitamin D in pregnant women with hypoparathyroidism poses no risk of congenital CV abnormalities.
Why the study?
Concern existed that vitamin D given to pregnant women might cause congenital cardiovascular abnormalities, prompting investigation of fetal hazards in treated women.
Does pharmacologic vitamin D cause congenital cardiovascular abnormalities in pregnant women with hypoparathyroidism?
Does pharmacologic vitamin D cause congenital cardiovascular abnormalities in pregnant women with hypoparathyroidism?
A 1971 letter to the editor discussing the investigation of potential congenital cardiovascular risks associated with pharmacologic vitamin D use during pregnancy.
Answers are grounded in this paper and cite their sources.
Reported safety does not support changing vitamin D dosing in hypoparathyroid pregnancy; leaves open need for prospective trials.
Letters, Comments, and Corrections1 November 1971No Risk from Vitamin D in PregnancyLUCY S. GOODENDAY, M.D., GILBERT S. GORDAN, M.D., PH.D.LUCY S. GOODENDAY, M.D., GILBERT S. GORDAN, M.D., PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-5-807_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In 1966 the ANNALSpublished an article by Dr. Helen Taussig (1), in which she expressed concern that vitamin D, if given to pregnant women, might cause congenital cardiovascular abnormalities. At the time this was published we were taking care of women with hypoparathyroidism who were taking pharmacologic doses of vitamin D to maintain normal serum calcium and phosphate levels. Inspired by reports in the lay press, several of these women expressed concern about the possible danger of this treatment to their unborn children. To ascertain the fetal hazards of this treatment we decided to investigate the...References1. TAUSSIG H: Possible injury to the cardiovascular system from vitamin D. Ann Intern Med 65:1195-1200, 1966 LinkGoogle Scholar2. FRIEDMANROBERTS WW: Vitamin D and the supravalvar aortic stenosis syndrome. The transplacental effects of vitamin D on the aorta of the rabbit. Circulation 34:77-86, 1966 CrossrefMedlineGoogle Scholar3. DEMOLECHRIST VA: Wirkung des D-Vitamins am nebenschilddrüsenexstirpierten Hund. Arch Exp Path Pharm 146:24, 1929 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReferencesVitamin D and maternal and child health: Overview and implications for dietary requirementsSpezielle Arzneimitteltherapie in der SchwangerschaftVitamin D: Cardiovascular Function and DiseaseMicronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficienty or excess. Part II - Vitamin D, Vitamin A, Iron, Zinc, Iodine, Essential Fatty AcidsVitamin D inadequacy in pregnancy: biology, outcomes, and interventionsRole of Vitamin D for Cardiovascular HealthMaternal vitamin D status during pregnancy and child outcomesThe Effect of High-Dose Vitamin D Supplementation on Serum Vitamin D Levels and Milk Calcium Concentration in Lactating Women and Their InfantsDrug administration to the pregnant or lactating woman: A reference guide for dermatologistsRequirements and upper limits of vitamin D intake in the term neonate, infant, and older childDisorders of the Parathyroid Glands and Vitamin D during PregnancyHigh concentrations of vitamin D2 in human milk associated with pharmacologic doses of vitamin D2Endocrine Regulation of Calcium Homeostasis During PregnancyVitamin Excess and ToxicityNutritional Deficiencies and Excesses 1 November 1971Volume 75, Issue 5Page: 807-808KeywordsCalciumChildrenHypoparathyroidismPhosphatesPregnancyVitamin D Issue Published: 1 November 1971 PDF downloadLoading ...
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Goodenday et al. (1971) conducted a letter in Pregnancy with hypoparathyroidism. Vitamin D was evaluated on Congenital cardiovascular abnormalities / fetal hazards. Pharmacologic doses of vitamin D in pregnant women with hypoparathyroidism were reported to pose no risk of congenital cardiovascular abnormalities.
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