Key result
Elevated pre-transplant CA-125 linked to ~294% higher long-term mortality after cardiac transplantation.
Why the study?
The relationship between high CA-125 levels and long-term prognosis after cardiac transplantation in chronic heart failure patients was unclear.
Does elevated CA-125 (>35 U/ml) predict long-term mortality in noncongestive patients undergoing cardiac transplantation?
Cohort (n=55)
Does elevated CA-125 (>35 U/ml) predict long-term mortality in noncongestive patients undergoing cardiac transplantation?
Elevated pre-transplant CA-125 levels (>35 U/ml) are associated with significantly worse long-term survival in noncongestive patients undergoing cardiac transplantation.
May flag higher-risk noncongestive transplant candidates; leaves open incremental value over existing models pending prospective validation.
AIM: To evaluate the possible relationship between high levels of CA-125 and long-term prognosis in chronic heart failure patients after they undergo a cardiac transplantation (CT). MATERIALS & METHODS: We retrospectively studied all patients who underwent a CT and had a previous determination of CA-125. Congestive patients and those whose survival was <1 year after CT were excluded. RESULTS: Of 55 patients, 23 had elevated CA-125 levels (>35 U/ml). After CT, survival was significantly inferior in this group (96.3 vs 81%, 84.9 vs 64%, 70.7 vs 32.9% at 2, 5 and 8 years, p = 0.014). CA-125 >35 U/ml was the only factor independently associated to long-term mortality (OR: 3.94; 95% CI: 1.2-12.82; p = 0.023). CONCLUSION: Noncongestive patients with high levels of CA-125 had inferior long-term survival after CT.
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Becerra‐Muñoz et al. (2017) conducted a cohort in chronic heart failure after cardiac transplantation (n=55). Elevated CA-125 levels (>35 U/ml) vs. CA-125 levels ≤35 U/ml was evaluated on long-term mortality (OR 3.94, 95% CI 1.2-12.82, p=0.023). Elevated pre-transplant CA-125 levels (>35 U/ml) were independently associated with increased long-term mortality after cardiac transplantation (OR 3.94; 95% CI 1.2-12.82; p=0.023).
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