Key result
Low CA-125 is linked to ~2-fold higher survival in decompensated heart failure.
Why the study?
Patients with decompensated congestive heart failure often have elevated CA-125 levels due to systemic congestion, but a subgroup presents with normal CA-125 levels whose clinical and prognostic profiles are not well characterized.
Does CA-125 level predict mortality and clinical profiles in patients hospitalized for decompensated congestive heart failure with isolated systemic congestion?
Population
166 patients hospitalized for decompensated congestive heart failure with isolated systemic congestion pattern
Comparison
CA-125 > 50 U/mL vs CA-125 ≤ 50 U/mL
Design
Retrospective cohort study
Authors
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Should not yet guide management in decompensated HF; leaves open incremental prognostic value beyond standard markers.
Cohort (n=166)
Does CA-125 level predict mortality and clinical profiles in patients hospitalized for decompensated congestive heart failure with isolated systemic congestion?
Absolute Event Rate: 50% vs 25%
p-value: p=<0.05
In patients with decompensated congestive heart failure and isolated systemic congestion, a low CA-125 level (≤ 50 U/mL) identifies a subgroup with a higher proportion of preserved ejection fraction and significantly better survival.
López‐Vilella et al. (2025) conducted a cohort in Decompensated congestive heart failure (n=166). Low CA-125 (≤ 50 U/mL) vs. High CA-125 (> 50 U/mL) was evaluated on Survival at the end of follow-up (p=<0.05). In patients with decompensated congestive heart failure, a low CA-125 level (≤50 U/mL) was associated with a higher probability of survival at the end of follow-up (>50% vs ~25%, p<0.05).
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