Key result
Losartan and ifetroban reduce blood pressure across all phases of 2K,1C hypertension in rats.
Why the study?
The role of AT1 and TxA2/PGH2 receptors in maintaining hypertension throughout different phases of 2K,1C Goldblatt hypertension in rats was unclear despite changes in plasma renin activity.
Does losartan or ifetroban reduce blood pressure in 2K,1C Goldblatt hypertensive rats across different phases of hypertension?
Population
2K,1C Goldblatt hypertensive rats in early, intermediate, and late phases and age-matched sham-operated controls
Comparison
Losartan (AT1 receptor antagonist) vs ifetroban (TxA2/PGH2 receptor antagonist) vs vehicle
Design
Preclinical study with direct arterial pressure measurement
Follow-up
3 days
Authors
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Does not warrant clinical adoption in renovascular hypertension; leaves open translation of receptor blockade effects to humans.
Does losartan or ifetroban reduce blood pressure in 2K,1C Goldblatt hypertensive rats across different phases of hypertension?
AT1 and TxA2/PGH2 receptors maintain hypertension throughout the evolution of 2K,1C Goldblatt hypertension in rats, as demonstrated by the blood pressure-lowering effects of losartan and ifetroban.
Wilcox et al. (1996) studied 2K,1C Goldblatt hypertension. Losartan and ifetroban vs. Vehicle was evaluated on Mean arterial pressure (MAP). Both losartan and ifetroban significantly reduced blood pressure in the early, intermediate, and late phases of 2K,1C hypertension in rats.
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