Key result
Cardiac-gated CT suggests a 10 mm safety margin for LAD delineation in left-sided breast cancer.
Why the study?
Cardiac toxicity after breast cancer radiation therapy is partly due to large radiation doses to coronary arteries, and homogeneous delineation of the LAD is needed to achieve robust dose constraints.
What is the appropriate safety margin for delineating the left anterior descending artery during radiation therapy planning in patients with left-sided breast cancer?
Observational (n=45)
What is the appropriate safety margin for delineating the left anterior descending artery during radiation therapy planning in patients with left-sided breast cancer?
A 10 mm diameter cylinder safety margin is suggested for delineating the LAD during radiation therapy planning for left-sided breast cancer to account for cardiac movement and vessel diameter.
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May support 10 mm LAD margin in left-sided breast cancer RT planning; leaves open prospective validation before practice change.
Nicolas et al. (2020) conducted an observational in Left-sided breast cancer (n=45). Cardiac-gated computed tomography was evaluated on Left anterior descending artery (LAD) diameter and movements. Cardiac-gated CT analysis of patients with left-sided breast cancer showed LAD diameter decreases from 4.9 mm at the ostium to 3.1 mm distally, suggesting a 10 mm safety delineation margin.
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