February 17, 2016Seminars in Thrombosis and Hemostasis
Platelet Function Testing in Patients on Antiplatelet Medications
Key result
Platelet function testing shows no benefit for guiding antiplatelet therapy in PCI patients.
Why the study?
There is interindividual variability in response to antiplatelet medications after PCI, and the clinical benefit of platelet function testing to guide treatment adjustments remains uncertain.
Does platelet function testing to guide antiplatelet treatment adjustments improve clinical outcomes in patients undergoing PCI?
Population
Patients undergoing PCI on antiplatelet medications
Comparison
Platelet function testing-guided treatment adjustments vs standard treatment
Design
Review
Authors
Discussion
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Member takes
Implication
Does not support routine platelet function testing to guide antiplatelet therapy in PCI; leaves open whether refined strategies improve outcomes in future trials.
Structured PICO
Does platelet function testing to guide antiplatelet treatment adjustments improve clinical outcomes in patients undergoing PCI?
P
Population
Patients undergoing percutaneous coronary intervention (PCI) on antiplatelet medications
I
Intervention
Platelet function testing to guide antiplatelet treatment adjustments
O
Outcome
Ischemic events (stent thrombosis, myocardial infarction, cardiovascular mortality) and bleeding events
Although platelet function testing has prognostic value for predicting thrombotic and bleeding risks, current randomized trials do not support routine antiplatelet treatment adjustments based on these tests.
Cite This Study
Aradi et al. (2016) conducted a review in Patients undergoing percutaneous coronary intervention (PCI) on antiplatelet medications. Platelet function testing was evaluated. Platelet function testing has prognostic value for ischemic and bleeding events in PCI patients, but available randomized trials show no benefit of modifying antiplatelet treatment based on results.