Key result
Oral high-virulent TGE virus protects swine from clinical infection unlike IM inoculation.
Why the study?
The relationship between active immunity to transmissible gastroenteritis virus and serum immunoglobulin A antibody titer in swine was unclear.
Population
Swine naturally infected or experimentally inoculated with transmissible gastroenteritis virus
Comparison
High-virulent vs low-virulent TGE virus inoculated orally or intramuscularly
Design
Preclinical experimental study
Follow-up
Up to 260 days post-inoculation
Authors
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May inform mucosal vaccination in swine; leaves open whether IgA correlates predict protection in other models or species.
Serum IgA antibody titer, rather than virus-neutralizing antibody titer, appears to be a reliable indicator of active immunity to transmissible gastroenteritis virus in swine.
Kodama et al. (1981) studied Transmissible gastroenteritis (TGE). Oral inoculation with high-virulent TGE virus vs. IM or oral inoculation with low-virulent TGE virus was evaluated on Serum IgA antibody titer and clinical signs of infection upon challenge. Oral inoculation with high-virulent TGE virus elicited serum IgA antibody titers of 2 to 512 and protected swine from clinical infection upon challenge, unlike IM inoculation.