Key result
Oral exposure to TGE virus in swine induced significantly greater MIF production by intestinal lamina propria lymphocytes than splenic lymphocytes (p≤0.01), whereas subcutaneous exposure favored splenic production.
Population
Swine, including animals orally exposed to transmissible gastroenteritis virus, subcutaneously exposed to…
Comparison
Oral or subcutaneous exposure to TGE virus. vs Unexposed swine.
Design
Preclinical
Follow-up
6 to 30 days, or 7 to 9.5 months post-exposure
Authors
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Weak localized CMI in TGE swine cautions against overreliance on systemic responses; leaves open mucosal CMI contributions to intestinal coronavirus protection.
p-value: p=≤0.01
The route of TGE virus exposure in swine determines the primary site of cell-mediated immunity, with oral exposure favoring local intestinal immunity and subcutaneous exposure favoring systemic immunity.
Frederick et al. (1976) studied Transmissible gastroenteritis (TGE) viral infection. Oral or subcutaneous exposure to TGE virus vs. Unexposed swine was evaluated on Macrophage migration inhibition factor (MIF) production by intestinal lamina propria (LP) and splenic lymphocytes (p=≤0.01). Oral exposure to TGE virus in swine induced significantly greater MIF production by intestinal lamina propria lymphocytes than splenic lymphocytes (p≤0.01), whereas subcutaneous exposure favored splenic production.
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