Key result
Autopsies in aortitis syndrome reveal diffuse myocardial fibrosis, marked LVH, coronary narrowing, and aortic insufficiency.
Why the study?
The relationship between cardiac lesions and aortitis syndrome, including the development of aortic valvular insufficiency, was not fully understood.
Case Report (n=5)
No
In aortitis syndrome, prognosis is largely dependent on the severity of heart failure, aortic insufficiency, and hypertension, driven by myocardial fibrosis and valvular ring dilatation.
Myocardial involvement may drive heart failure risk in aortitis syndrome; hypothesis-generating from 5 cases and leaves open need for larger studies.
The clinical findings and the necropsy reports of 5 cases of aortitis syndrome have been presented. In addition to the typical arterial changes, diffuse myocardial fibrosis with marked left ventricular hypertrophy was seen at necropsy. The relationship between these cardiac lesions and aortitis syndrome was discussed. The development of aortic valvular insufficiency in this disease was not infrequently found, and was thought to be due to the dilatation of valvular ring and/or the extension of the inflammatory change of the aorta to the aortic valve itself. The prognosis of the disease seems to be dependent largely on the severity of heart failure, aortic insufficiency and hypertension.
No takes yet. Share an insight, caveat, or question.
Saito et al. (1972) conducted a case report in Aortitis syndrome (n=5). Aortitis syndrome was evaluated on Pathological findings of the heart, coronary artery, and aortic valve. Autopsy of 5 cases of aortitis syndrome revealed diffuse myocardial fibrosis with marked left ventricular hypertrophy, coronary artery narrowing, and aortic valvular insufficiency.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: