Key result
Acute upper GI bleeding carries ~6% mortality, linked to older age, orthostatic hypotension, and steroid use.
Why the study?
The prevalence and etiology of acute upper gastrointestinal bleeding have changed due to Helicobacter pylori eradication, prevention of variceal bleeding, and increased NSAID use.
Population
572 adults admitted with or developing AUGIB in Shiraz, Iran
Comparison
Patients with different causes of AUGIB and risk factors for mortality
Design
Prospective observational study in two university hospitals
Follow-up
15 days
Authors
Loading...
NSAID-associated ulcers predominate in this AUGIB cohort; supports targeted prevention but leaves generalizability and causality open.
Observational (n=572)
Yes
In a southern Iranian cohort, gastric ulcers were the leading cause of acute upper gastrointestinal bleeding, often associated with NSAID use, with higher mortality seen in older patients and those with hemodynamic instability or concomitant steroid use.
Pirastehfar et al. (2010) conducted an observational in Acute upper gastrointestinal bleeding (n=572). Risk factors (older age, orthostatic hypotension, steroid use) was evaluated on Mortality. Gastric and duodenal ulcers were the most common causes of acute upper gastrointestinal bleeding (44%), with an overall mortality of 6% that was significantly increased by older age, orthostatic hypotension, and steroid use.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: