Key result
LBBAP upgrade improves LVEF by ~18% and narrows QRS in a patient with PICM.
Why the study?
Long-term right ventricular pacing may cause pacing-induced cardiomyopathy, and conduction system pacing has recently emerged as a physiological alternative to biventricular pacing for treatment.
Does upgrading to left bundle branch area pacing improve left ventricular function and symptoms in a patient with pacing-induced cardiomyopathy?
Case Report (n=1)
No
Does upgrading to left bundle branch area pacing improve left ventricular function and symptoms in a patient with pacing-induced cardiomyopathy?
Upgrading to left bundle branch area pacing can successfully reverse pacing-induced cardiomyopathy and improve functional capacity in patients with high-burden right ventricular pacing.
Supports physiologic pacing to prevent or reverse PICM; extends treatment options beyond BVP in current guidelines.
Right ventricular pacing (RVP) is conventionally preferred in the treatment of patients with atrioventricular block. However, long-term RVP may lead to pacing-induced cardiomyopathy (PICM), characterized by new-onset or worsening ventricular functions due to dyssynchronous ventricular electrical activation, abnormal ventricular remodeling, and increased energy expenditure. Historically, biventricular pacing (BVP) and guideline-directed medical therapy were the only treatment option for PICM. Recently, conduction system pacing, including left bundle branch area pacing (LBBaP), has emerged as a physiological alternative to BVP, showing better results in electro-mechanical ventricular synchronization and hemodynamic parameters compared to BVP. We present a case involving a patient from whom the PICM was successfully recovered shortly after LBBaP.
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Mert Doğan (2024) conducted a case report in Pacing-induced cardiomyopathy (n=1). Left bundle branch area pacing (LBBaP) vs. Right ventricular pacing (baseline) was evaluated on Left ventricular ejection fraction (LVEF) and paced QRS duration. Upgrading to left bundle branch area pacing in a patient with pacing-induced cardiomyopathy improved left ventricular ejection fraction from 27% to 45% and reduced paced QRS duration from 160 ms to 90 ms at 3 months.
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