What question did this study set out to answer?

To estimate the population-level prevalence of prediabetes and undiagnosed type 2 diabetes in Canadian adults comparing fasting plasma glucose and hemoglobin A1c diagnostic screening criteria.

April 7, 2015Diabetes Care

Prevalence of Prediabetes and Undiagnosed Diabetes in Canada (2007–2011) According to Fasting Plasma Glucose and HbA1c Screening Criteria

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Authors

LRLaura C. Rosella3M (United States)MLMichael LebenbaumUniversity of Wisconsin–Madison TFTiffany FitzpatrickUniversity of Toronto

Discussion

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Implication

Population-based survey finds higher prevalence of undiagnosed diabetes and prediabetes using hemoglobin A1c versus fasting glucose in adults, highlighting how screening criteria alter detection.

Key Points

To estimate the population-level prevalence of prediabetes and undiagnosed type 2 diabetes in Canadian adults comparing fasting plasma glucose and hemoglobin A1c diagnostic screening criteria.
Analyzed pooled fasting subsamples from the Canadian Health Measures Survey (2007–2011) restricted to nonpregnant adults aged ≥20 years (N = 3,494).
Defined undiagnosed diabetes as FPG ≥7.0 mmol/L or HbA1c ≥6.5% (≥48 mmol/mol) and prediabetes as FPG 6.1–<7.0 mmol/L or HbA1c 6.0%–<6.5% (42–<48 mmol/mol) using survey weights and bootstrap confidence intervals.
Undiagnosed type 2 diabetes prevalence was 1.13% (95% CI 0.79, 1.62) using FPG (accounting for ~20% of total diabetes) versus 3.09% (95% CI 1.97, 4.81) using HbA1c (accounting for ~41% of total diabetes).
HbA1c criteria yielded a threefold higher prediabetes prevalence overall and a sixfold higher prevalence among females compared to FPG criteria (13.31% vs. 2.22%).
Screening with FPG alone identified older individuals with undiagnosed diabetes (mean age 58.7 years [95% CI 59.9, 63.4]), whereas HbA1c detected younger individuals with prediabetes who had lower BMI and waist circumference.

Cite This Study

Rosella et al. (2015) studied this question.

synapsesocial.com/papers/6aaf65977e8385fbd3d065c6 https://doi.org/10.2337/dc14-2474

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Implication

Population-based survey finds higher prevalence of undiagnosed diabetes and prediabetes using hemoglobin A1c versus fasting glucose in adults, highlighting how screening criteria alter detection.

Prevalence of Prediabetes and Undiagnosed Diabetes in Canada (2007–2011) According to Fasting Plasma Glucose and HbA1c Screening Criteria

Discussion

Member takes

Implication

Key Points

Cite This Study

Prevalence of Prediabetes and Undiagnosed Diabetes in Canada (2007–2011) According to Fasting Plasma Glucose and HbA1c Screening Criteria

Discussion

Member takes

Implication

Key Points

Cite This Study

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