Key result
Serum NGAL and urine KIM-1 outperform serum creatinine for early CIN diagnosis post-PCI.
Why the study?
Early changes in serum NGAL and urine KIM-1 after PCI and their diagnostic value for contrast-induced nephropathy were not well established.
Do serum NGAL and urine KIM-1 levels provide earlier diagnosis of contrast-induced nephropathy compared to serum creatinine in patients undergoing percutaneous coronary intervention?
Observational (n=240)
Do serum NGAL and urine KIM-1 levels provide earlier diagnosis of contrast-induced nephropathy compared to serum creatinine in patients undergoing percutaneous coronary intervention?
Serum NGAL and urine KIM-1 levels rise earlier than serum creatinine after PCI, offering potential as early diagnostic biomarkers for contrast-induced nephropathy.
NGAL and KIM-1 may enable earlier CIN detection post-PCI than creatinine; leaves open validation before routine clinical use.
BACKGROUND The aim of this study was to assess changes in serum neutrophil gelatinase-associated lipocalin (NGAL) and urine KIM-1 after percutaneous coronary intervention (PCI). MATERIAL AND METHODS A total of 240 patients receiving coronary stent implantation were selected. All patients were divided into 2 groups: a CIN group (n=25) and a non-CIN group (n=215). The serum creatinine (SCr), NGAL, and urine KIM-1 levels of the patients in both groups were measured before and after surgery, and the sensitivity of serum NGAL and urine KIM-1 in diagnosing CIN in the early stage was assessed by the area under receiver operating characteristic (ROC) curve (ROC-AUC). RESULTS In the CIN group, the serum NGAL and urine KIM-1 levels started to rise at 6 h after surgery. The serum NGAL and urine KIM-1 levels in CIN group were significantly higher than those in the non-CIN group at 6, 12, 24, and 48 h after surgery. However, the SCr levels in the CIN group were not higher than those in the non-CIN group at 6 h after surgery. At 6, 12, and 24 h after PCI, the AUCs for serum NGAL and urine KIM-1 were increased compared with that for SCr, while the AUCs for serum NGAL and urine KIM-1 were decreased at 48 h after PCI compared with that for SCr. CONCLUSIONS Serum NGAL and urine KIM-1 levels in the patients after coronary stent implantation can reflect the changes in renal functions early, thus providing a certain basis for the early diagnosis of CIN.
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Liao et al. (2019) conducted an observational in Contrast-Induced Nephropathy (CIN) (n=240). Serum NGAL and urine KIM-1 vs. Serum creatinine was evaluated on Diagnosis of CIN in the early stage assessed by area under receiver operating characteristic curve (ROC-AUC). Serum NGAL and urine KIM-1 levels were significantly higher in the CIN group at 6 to 48 hours post-PCI, demonstrating higher AUCs than serum creatinine for early diagnosis.
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