Key result
Plasma proscillaridin A-immunoreactive material correlates with systolic and pulse blood pressure.
Why the study?
A material crossreacting with proscillaridin A antibodies and inhibiting the sodium pump was identified in human plasma, with unclear identity and physiological role.
Observational
The identification of an endogenous proscillaridin A-like compound and its specific binding protein supports the existence of a novel class of cardiotonic steroid hormones involved in blood pressure regulation.
May implicate endogenous Na/K-ATPase inhibitors in hypertension; leaves open their identity and causal role.
A material crossreacting with antibodies against the bufadienolide proscillaridin A and inhibiting the sodium pump was found in human blood plasma. The concentration of the material with a retention time similar to ouabain in a reversed phase HPLC correlated to systolic blood pressure and pulse pressure. Affinity purification of this compound from bovine adrenals resulted in the isolation of a compound with molecular mass of 600 Da that was not identical with ouabain. Consistent with the postulate that endogenous ouabain and proscillaridin A immunoreactivities may belong to a new class of cardiotonic steroid hormones, a protein of Mr = 60 kDa has been found in bovine serum by affinity-labeling with N-hydroxysuccimidyl digoxigenin-3-O-methylcarbonyl-epsilon-aminocaproate.
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Schneider et al. (1998) conducted an observational in Blood pressure. Proscillaridin A immunoreactivity was evaluated on Correlation with systolic blood pressure and pulse pressure. The concentration of a proscillaridin A-immunoreactive material in human blood plasma correlated with systolic and pulse blood pressure.
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