Key result
Porcine aortic roots expand ~40% during pressurization, suggesting unstented xenograft valves require substantial oversizing.
Why the study?
Proper sizing of aortic allografts and stentless porcine xenograft valves for the recipient aortic root is critical but not well characterized in terms of dynamic aortic root expansion.
How does the aortic root expand under varying pressures in a porcine model, and what are the implications for bioprosthetic valve sizing?
Population
Isolated porcine hearts (beating and arrested)
Comparison
Dynamic and static aortic root expansions at varying pressures
Authors
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Porcine model enables dynamic aortic root measurements; leaves open translation to human allograft sizing.
How does the aortic root expand under varying pressures in a porcine model, and what are the implications for bioprosthetic valve sizing?
Aortic root expansion is highly pressure-dependent, suggesting unstented xenograft valves should be sized 30% to 40% larger than the collapsed recipient aorta.
Veselý et al. (1991) studied Bioprosthetic valve sizing. Cyclic pressurizing vs. Rest was evaluated on Aortic root expansion. Aortic root expansion in porcine hearts reached up to 40% between rest and cyclic pressurizing to 100 mmHg, suggesting unstented xenograft valves should be sized 30% to 40% larger than the collapsed aorta.