Key result
IABC fails to improve myocardial perfusion or ischemic dyskinesis in dogs.
Why the study?
The effect of intra-aortic balloon counterpulsation on motion and perfusion of acutely ischemic myocardium was unclear.
Does intra-aortic balloon counterpulsation improve motion and perfusion of acutely ischemic myocardium in a canine model?
Population
30 open-chest dogs with acute ischemic myocardium induced by circumflex coronary artery ligation
Comparison
Baseline ischemic measurements vs intra-aortic balloon counterpulsation with or without norepinephrine or nitroprusside
Design
Experimental echocardiographic study
Authors
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IABP may not enhance perfusion in acute ischemia; leaves open its role in human MI or shock pending clinical data.
Does intra-aortic balloon counterpulsation improve motion and perfusion of acutely ischemic myocardium in a canine model?
Absolute Event Rate: 28% vs 30%
In a canine model of acute myocardial ischemia, intra-aortic balloon counterpulsation failed to improve myocardial perfusion or significantly reverse ischemic dyskinesis.
Kerber et al. (1976) studied Acute ischemic myocardium (n=30). Intra-aortic balloon counterpulsation (IABC) vs. Baseline ischemia (pre-IABC) was evaluated on Myocardial perfusion of the ischemic area. Intra-aortic balloon counterpulsation had little effect on ischemic dyskinesis and failed to improve perfusion of the acutely ischemic myocardium (30.0 to 28.0 cc/100 g/min) in dogs.
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