Key result
Second-line chemotherapy clears myocardial lesions and prevents arrhythmia recurrence in a secondary non-Hodgkin's lymphoma patient.
Why the study?
Cardiac involvement of systemic non-Hodgkin's lymphoma is difficult to diagnose before autopsy and ventricular arrhythmias are unusual in this setting.
Case Report (n=1)
Secondary myocardial non-Hodgkin's lymphoma can present with sustained monomorphic ventricular tachycardia and may be successfully treated with chemotherapy.
Suggests chemotherapy may control arrhythmias in secondary myocardial lymphoma; hypothesis-generating and requires validation before practice change.
Systemic non-Hodgkin's lymphoma can affect the myocardium, particularly in immunocompromised patients. When present, symptoms and signs are usually nonspecific, making the diagnosis of cardiac involvement very difficult before an autopsy. Ventricular arrhythmias are also unusual in this setting. We describe a case of secondary myocardial non-Hodgkin's lymphoma presenting with sustained monomorphic ventricular tachycardia and thickening of the basal interventricular septum. Complete remission of myocardial lesions was observed after completion of second-line chemotherapy treatment, without further recurrences of arrhythmias in eight months.
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Chemello et al. (2011) conducted a case report in Secondary myocardial non-Hodgkin's lymphoma with ventricular tachycardia (n=1). Second-line chemotherapy treatment was evaluated on Complete remission of myocardial lesions and recurrence of arrhythmias. Second-line chemotherapy treatment resulted in complete remission of myocardial lesions and no recurrence of arrhythmias at eight months in a patient with secondary myocardial non-Hodgkin's lymphoma.
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