Key result
Increasing blood resistivity to myocardial levels reduces spatial dipole moment peak M1 by ~67%.
Why the study?
The effect of intracardiac blood resistivity changes on the spatial vectorcardiogram was not well characterized in vivo.
Population
Dogs in vivo
Comparison
Exchange transfusions raising hematocrit over 70% or lowering to 16% vs control hematocrit
Design
Preclinical experimental study with analog computer processing of vector leads
Authors
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Hypothesis-generating for blood resistivity effects on vectorcardiograms; human validation needed before clinical consideration.
Normal intracardiac blood significantly alters the spatial vectorcardiogram, increasing early spatial dipole moments and decreasing late ones due to changes in electrical resistivity.
Nelson et al. (1972) studied this question. Exchange transfusions to alter hematocrit and blood resistivity vs. Control values (blood resistivity of 150 ohm-cm) was evaluated on Spatial dipole moment (M) peaks (M1, M2, M3). Increases in blood resistivity to values near myocardium decreased spatial dipole moment peaks M1 to 33% and M2 to 40% of control values, while M3 rose to 125%.
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