Key result
Lower serum osteocalcin is linked to ~77% greater carotid plaque risk per SD in T2D.
Why the study?
The association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes was not well established.
Is serum osteocalcin level associated with carotid atherosclerosis in patients with type 2 diabetes?
Cross-Sectional (n=817)
Is serum osteocalcin level associated with carotid atherosclerosis in patients with type 2 diabetes?
Odds Ratio: 1.77 (95% CI 1.23–2.76)
p-value: p=0.005
Lower serum osteocalcin levels are independently associated with an increased risk of carotid atherosclerosis in patients with type 2 diabetes.
Should not change practice; hypothesis-generating for osteocalcin in T2D atherosclerosis risk assessment.
OBJECTIVE: To investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes. METHODS: We performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound. RESULTS: The crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P <0.001), respectively. Osteocalcin levels were associated inversely with age, fasting serum insulin, HOMA-IR, ALT, triglycerides, total cholesterol, LDL- cholesterol, CRP (all P<0.001) and positively with adiponectin and HOMA-B (all P<0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher risk for carotid plaques (OR 1.77 for 1 SD decrease in osteocalcin, 95% CI 1.23-2.76, p=0.005). These associations remained significant after further adjustment for potential confounder. CONCLUSIONS: Serum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.
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Li et al. (2013) conducted a cross-sectional in Type 2 diabetes (n=817). Decreased serum osteocalcin vs. Higher serum osteocalcin levels was evaluated on Carotid atherosclerotic plaques (OR 1.77, 95% CI 1.23-2.76, p=0.005). A 1 SD decrease in serum osteocalcin was associated with a significantly higher risk of carotid atherosclerotic plaques (OR 1.77) in patients with type 2 diabetes.
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