Key result
Mixed poliovirus and ME virus infection drives ME-typical membrane damage regardless of poliovirus reproduction.
Why the study?
The distinct cell surface alterations induced by mixed infection with poliovirus and ME virus in HEp-2 cells were not fully characterized.
In HEp-2 cells mixedly infected with poliovirus and ME virus, the ME virus dictates the resulting cell surface alterations and cytolytic membrane damage.
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ME virus dominance in mixed infections may guide antiviral research; leaves open in vivo relevance and clinical implications.
Zeichhardt et al. (1982) studied HEp-2 cells infected with picornaviruses. Mixed infection with poliovirus and ME virus vs. Single infection with poliovirus or ME virus was evaluated on Cell surface alterations and cytolytic membrane damage. Mixed infection of HEp-2 cells with poliovirus and ME virus led to cell surface alterations and cytolytic membrane damage typical for ME virus, irrespective of poliovirus reproduction.
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