Age and its relationship to acute coronary syndromes in the Saudi Project for Assessment of Coronary Events (SPACE) registry: The SPACE age study
Key result
Age >70 years in ACS is linked to ~7% in-hospital mortality and less aggressive treatment.
- P<0.001
- n=5,055
Why the study?
Young and old ACS patients have unique risk factors and present differently, but differences in management and outcomes across age groups were not well characterized in Saudi Arabia.
Comparison
ACS patients divided into four age groups (≤40, 41-55, 56-70, ≥70 years)
Design
Prospective multi-hospital registry
Follow-up
In-hospital
Authors
Discussion
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Member takes
Implication
Registry data on age-stratified ACS risk and outcomes support hypothesis generation; prospective trials needed before practice change.
Study Design
Type
Observational (n=5,055)
Multicenter
Yes
Structured PICO
P
Population
5,055 patients with acute coronary syndrome admitted to 17 hospitals in Saudi Arabia, stratified by age to assess risk profiles, management, and in-hospital outcomes.
C
Comparator
Comparison across age groups (≤40, 41-55, 56-70, and ≥70 years)
O
Outcome
Prevalence, utilization, and in-hospital mortalityhard clinical
Main Result
p-value: p=<0.001
Older patients with acute coronary syndrome present differently, are treated less aggressively with invasive strategies, and experience higher in-hospital mortality compared to younger patients.
Cite This Study
AlSaif et al. (2011) conducted an observational in acute coronary syndrome (n=5,055). Older age (>70 years) vs. Younger age (<70 years) was evaluated on in-hospital mortality (p=<0.001). Older age (>70 years) in patients with acute coronary syndrome was associated with higher in-hospital mortality (7% vs 1.6-3% in patients <70 years, p<0.001) and less aggressive treatment.