Key result
Mas deficiency reduces HRV in females and increases sympathetic tone across sexes in mice.
Why the study?
A significant genetic influence on heart rate variability is suggested, but the specific genes involved are ill-defined, including the role of the Mas-protooncogene.
Does Mas protooncogene deficiency alter heart rate and blood pressure variability in mice?
Population
Mas-deficient mice and control mice
Comparison
Mas protooncogene knockout vs control
Design
Preclinical study
Follow-up
30 minutes recording period
Authors
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Mas receptor deficiency alters autonomic control in mice; leaves open its role in human cardiovascular variability.
Does Mas protooncogene deficiency alter heart rate and blood pressure variability in mice?
The Mas-protooncogene appears to be an important determinant of heart rate and blood pressure variability, as evidenced by altered cardiovascular variability and increased sympathetic tone in Mas-deficient mice.
Walther et al. (2000) studied Mas-deficient mice. Mas protooncogene deficiency vs. Controls was evaluated on Heart rate and blood pressure variability. Mas-deficient mice exhibited significant alterations in cardiovascular variability, including reduced heart rate variability in females and increased sympathetic tone in both genders.
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