Key result
Lifelong overexpression of the GLUT1 glucose transporter in mice limited age-related diastolic dysfunction and improved functional recovery after ischemia and reperfusion.
Why the study?
Does lifelong overexpression of the GLUT1 glucose transporter improve functional recovery after ischemia in isolated mouse hearts?
Does lifelong overexpression of the GLUT1 glucose transporter improve functional recovery after ischemia in isolated mouse hearts?
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Maintaining high rates of myocardial glucose utilization might retard age-related myocardial dysfunction and promote functional recovery after ischemia.
E. Dale Abel (2007) conducted an editorial in Ischemic heart disease. Lifelong overexpression of the GLUT1 glucose transporter was evaluated. Lifelong overexpression of the GLUT1 glucose transporter in mice limited age-related diastolic dysfunction and improved functional recovery after ischemia and reperfusion.
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