What is the clinical evidence from this study?

Study design: Observational. Population: Coronary artery disease (n=138). Intervention: Coronary artery disease vs. Heart defects. Primary outcome: PAI-1 gene expression and secretion in adipose tissue and plasma PAI-1 concentration.

What does this research mean for the field?

Coronary artery disease is associated with increased PAI-1 gene expression and secretion across subcutaneous, epicardial, and perivascular adipose tissues, with epicardial adipose tissue exhibiting the highest PAI-1 production. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the expression and secretion of plasminogen activator inhibitor-1 (PAI-1) across subcutaneous, epicardial, and perivascular fat depots in relation to coronary artery disease severity.

February 2, 2022Russian Journal of CardiologyOpen Access

Features of plasminogen activator inhibitor-1 synthesis by local fat depots of different localization in cardiovascular diseases

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Key result

CAD is linked to increased PAI-1 expression and secretion in adipose tissue versus heart defects.

n=138

Why the study?

The features of expression and secretion of plasminogen activator inhibitor-1 by different local adipose tissue depots in relation to coronary artery disease severity were not well characterized.

Key Points

To evaluate the expression and secretion of plasminogen activator inhibitor-1 (PAI-1) across subcutaneous, epicardial, and perivascular fat depots in relation to coronary artery disease severity.
Analyzed 86 patients with coronary artery disease stratified by SYNTAX score (35 moderate [≤22], 22 severe [23–31], and 29 extremely severe [≥32]) alongside a comparison group of 52 patients with heart defects.
Collected subcutaneous, epicardial (EAT), and perivascular (PVAT) adipose tissue biopsies during elective surgery to measure PAI-1 gene expression and supernatant protein secretion alongside plasma concentrations.
Patients with coronary artery disease exhibited significantly increased PAI-1 gene expression and secretion across all three fat depots as well as higher circulating plasma PAI-1 compared to controls with heart defects.
Epicardial adipose tissue produced the highest levels of PAI-1 expression and secretion among all depots, with the lowest overall tissue and plasma PAI-1 levels observed in mild coronary involvement (SYNTAX score ≤22).
Plasma PAI-1 levels correlated directly with EAT secretion across all cohorts, whereas a direct correlation with PVAT secretion occurred exclusively in coronary artery disease; EAT PAI-1, plasma levels, and age predicted severe coronary disease.

Study Design

Type

Observational (n=138)

Structured PICO

Population

138 patients undergoing elective surgical intervention, including 86 with coronary artery disease of varying severity and 52 with heart defects as a comparison group.

Comparator

52 patients with heart defects

Outcome

PAI-1 gene expression and PAI-1 secretion in subcutaneous, epicardial, and perivascular adipose tissue, and plasma PAI-1 concentrationsurrogate

PAI-1 expression and secretion in epicardial adipose tissue, along with plasma PAI-1 levels, are elevated in CAD and serve as predictors of severe coronary involvement.

Discussion

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Implication

EAT PAI-1 expression may mark CAD severity; observational data leave open causal role or therapeutic targeting.

Cite This Study

Belik et al. (2022) conducted an observational in Coronary artery disease (n=138). Coronary artery disease vs. Heart defects was evaluated on PAI-1 gene expression and secretion in adipose tissue and plasma PAI-1 concentration. Coronary artery disease was associated with increased PAI-1 gene expression and secretion in subcutaneous, epicardial, and perivascular adipose tissue compared to patients with heart defects.

synapsesocial.com/papers/6ab1fe6782c78abca8c86fa5 https://doi.org/10.15829/1560-4071-2022-4866

Topics

Coronary artery disease

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Features of plasminogen activator inhibitor-1 synthesis by local fat depots of different localization in cardiovascular diseases

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Topics

Features of plasminogen activator inhibitor-1 synthesis by local fat depots of different localization in cardiovascular diseases

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider