Key result
Coarse AF is linked to ~45% higher cerebrovascular event rates than fine AF.
Why the study?
Atrial fibrillation is identified by two morphological forms, fine and coarse AF, but their associations with clinical parameters and vascular endpoints are unclear.
Does coarse atrial fibrillation compared to fine atrial fibrillation associate with a higher prevalence of cerebrovascular events in patients with AF?
Observational (n=811)
Does coarse atrial fibrillation compared to fine atrial fibrillation associate with a higher prevalence of cerebrovascular events in patients with AF?
Effect estimate: B 1.585
Absolute Event Rate: 19.6% vs 13.5%
p-value: p=0.031
Coarse atrial fibrillation on surface ECG is independently associated with a higher prevalence of prior cerebrovascular events compared to fine AF.
Coarse AF may signal higher cerebrovascular risk; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND: Atrial fibrillation (AF) is a frequent arrhythmia, associated with morbidity and mortality. It is identified by two types on surface electrocardiogram as fine and coarse AF. We aimed to search the association of subtypes of AF with clinical parameters. METHODS: Eight hundred and eleven consecutive patients, who had AF attack which lasted longer than 24 h or more, were evaluated along with clinical and laboratory data. RESULTS: Coarse AF was noticed in 51.7% (n = 419), and fine AF in 48.3% (n = 392). Sex was associated with subtype of AF such that coarse AF was present in 46.5% of male patients, but in 56.1% of female patients (p = 0.009). Coarse AF was present in 85.3% of patients with mitral stenosis, whereas it was present in 35.3% of patients with normal heart valve (p < 0.001). ). Patients having fine AF were significantly older than those having coarse AF (64 +/- 12, 57 +/- 13 years, p < 0.001). 19.6% of those with coarse AF had history of cerebrovascular event (CVE), whereas 13.5% of those with fine AF had history of CVE (p = 0.021). After controlling for age in the multivariable logistic regression analysis, presence of coarse AF (B = 1.585, p = 0.031) was found to be independently associated with the history of CVE. CONCLUSION: AF is identified by two morphological forms on the surface electrocardiogram. These two forms were found to be associated with different clinical parameters, acting on vascular endpoints differently.
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Yılmaz et al. (2006) conducted an observational in Atrial fibrillation (n=811). Coarse atrial fibrillation vs. Fine atrial fibrillation was evaluated on History of cerebrovascular event (CVE) (B 1.585, p=0.031). Coarse atrial fibrillation was independently associated with a history of cerebrovascular events compared to fine atrial fibrillation (19.6% vs 13.5%; P=0.031).
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