Key result
Once-daily felodipine ER matches twice-daily plain tablets, lowering blood pressure by ~15/12 mm Hg.
Why the study?
The comparative efficacy and tolerance of felodipine extended-release once daily versus plain tablets twice daily in treating hypertension were not established.
Does felodipine extended-release once daily reduce blood pressure as effectively as plain tablets twice daily in patients with hypertension?
Population
102 patients with supine DBP > 95 mm Hg after placebo and beta-blocker run-in
Comparison
Felodipine ER 10 mg once daily vs plain tablets 5 mg twice daily
Design
Randomized controlled trial
Follow-up
6 weeks
Authors
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Supports once-daily felodipine for adherence in hypertension on beta-blockers; leaves open relevance to contemporary regimens or outcomes.
RCT (n=102)
randomized
Does felodipine extended-release once daily reduce blood pressure as effectively as plain tablets twice daily in patients with hypertension?
Felodipine extended-release once daily is as effective and tolerable as plain tablets twice daily for the treatment of hypertension.
Hart et al. (1990) conducted an RCT in Hypertension (n=102). Felodipine extended-release (ER) tablets vs. Felodipine plain tablets 5 mg twice daily was evaluated on Blood pressure reduction at the end of the dosing interval. Felodipine extended-release tablets once daily reduced blood pressure by 15/12 mm Hg, demonstrating equivalent efficacy to plain tablets twice daily (13/11 mm Hg reduction).
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