Key result
Lacking standard modifiable risk factors in AMI is linked to ~145% higher in-hospital mortality.
Why the study?
The etiology and prevalence of AMI in patients without standard modifiable risk factors (SMuRFs) remain unclear, especially in European populations, and SMuRF-less patients may have worse short-term outcomes.
Do SMuRF-less patients with acute myocardial infarction have worse outcomes compared to those with standard modifiable risk factors?
Population
1011 consecutive AMI patients in Greece undergoing coronary angiography
Comparison
SMuRF-less patients vs patients with at least one SMuRF
Design
Prospective observational cohort study
Follow-up
Short-term (in-hospital and 30-day) and long-term follow-up
Authors
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SMuRF-less AMI patients may warrant closer in-hospital monitoring; this association leaves open causal mechanisms and targeted interventions.
Observational (n=1,011)
Do SMuRF-less patients with acute myocardial infarction have worse outcomes compared to those with standard modifiable risk factors?
Hazard Ratio: 2.45 (95% CI 1.36–4.41)
p-value: p=0.003
Patients with acute myocardial infarction lacking standard modifiable risk factors have worse short-term mortality and cardiovascular outcomes compared to those with risk factors, though long-term outcomes are similar.
Moysidis et al. (2025) conducted an observational in Acute myocardial infarction (n=1,011). Absence of standard modifiable risk factors (SMuRF-less) vs. Presence of at least one standard modifiable risk factor was evaluated on In-hospital all-cause death (aHR 2.45, 95% CI 1.36-4.41, p=0.003). Patients with AMI lacking standard modifiable risk factors had a higher risk of in-hospital all-cause death compared to those with risk factors (aHR 2.45; 95% CI 1.36-4.41; p=0.003).
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