Key result
Women with metabolic syndrome demonstrated a 5-fold increase in IL-6 and 4-fold increase in TNF-α gene expression in mesenteric adipose tissue, alongside a 3-fold decrease in adiponectin gene expression in omental adipose tissue compared to controls.
Case-Control (n=33)
No
Effect estimate: 5-fold greater
p-value: p=<0.05
Women with metabolic syndrome exhibit increased proinflammatory gene expression in mesenteric adipose tissue and decreased adiponectin expression in omental adipose tissue compared to healthy controls.
Supports adipose depot-specific inflammation in MS; hypothesis-generating and requires validation before clinical relevance.
BACKGROUND: The purpose of this research was to study the gene expression of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB), vascular endothelial growth factor A (VEGF-A) and adiponectin (AdipoQ) genes in the visceral (omental, mesenteric) and subcutaneous adipose tissue depots in metabolic syndrome (MS). We studied 23 women with MS, with a mean age of 50.7 ± 4.5 years and mean body mass index (BMI) of 45.6 ± 9.8 kg/m(2). The control group included 10 women, with a mean age of 40.6 ± 8.7 years and normal BMI (22.3 ± 3.7 kg/m(2)). The gene expression levels in the omental (OAT), mesenteric (MAT) and subcutaneous (SAT) adipose tissues were assessed by quantitative real-time PCR. FINDINGS: Increased gene expression levels of IL-6 and TNF-α were detected in MAT in patients with MS, compared with the control group (p < 0.05 and p < 0.005, respectively). Significant positive correlations were observed between IL-6 mRNA expression levels in OAT and the content of CD14 + cells in the peripheral blood (r = 0.55, p < 0.05), as well as between NF-κB and VEGF-A mRNA levels in OAT (r = 0.43, p < 0.05) in patients with MS. The AdipoQ gene expression levels in OAT were significantly decreased in women with MS compared with the control group (p < 0.05). In addition, there were inverse correlations between AdipoQ gene levels in MAT and serum CRP levels (r = -0.63, p < 0.05), as well as between AdipoQ gene levels in MAT and serum IL-6 levels (r = -0.46, p < 0.05). CONCLUSION: These data demonstrate that proinflammatory gene expression of MAT in women with MS was increased compared with the control group. The AdipoQ gene expression levels in OAT were significantly decreased in women with MS compared with the control group.
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Litvinova et al. (2014) conducted a case-control in Metabolic syndrome (n=33). Metabolic syndrome vs. Healthy women with normal BMI was evaluated on IL-6 gene expression in mesenteric adipose tissue (5-fold greater, p=<0.05). Women with metabolic syndrome demonstrated a 5-fold increase in IL-6 and 4-fold increase in TNF-α gene expression in mesenteric adipose tissue, alongside a 3-fold decrease in adiponectin gene expression in omental adipose tissue compared to controls.
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