Key result
Prior stroke is linked to a ~173% increase in late-life depression risk.
Why the study?
Associations between vascular risk factors and late-life depression are controversial.
Are vascular disease and risk factors associated with late-life depression in an older Korean community population?
Population
732 Korean community participants aged 65 and older
Comparison
Presence vs absence of vascular disease/risk factors including previous stroke, HDL cholesterol, hypertension, diabetes
Design
Cross-sectional study
Authors
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Stroke and low HDL link to late-life depression; hypothesis-generating for vascular mechanisms, causality unproven.
Cross-Sectional (n=732)
Are vascular disease and risk factors associated with late-life depression in an older Korean community population?
Odds Ratio: 2.73 (95% CI 1.37–5.59)
p-value: p=<0.01
Previous stroke and lower HDL cholesterol, but not hypertension or diabetes, are significantly associated with late-life depression in an older Korean population.
Kim et al. (2004) conducted a cross-sectional in Late-life depression (n=732). Previous stroke vs. No previous stroke was evaluated on Case-level depression (OR 2.73, 95% CI 1.37-5.59, p=<0.01). Previous stroke was significantly associated with late-life depression (OR 2.73) independently of disability, cognitive function, and APOE genotype.
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