Key result
Cardiac allograft intimal thickening contains host-derived cells alongside predominantly donor cells at two years.
Why the study?
The cellular origin of arterial intimal thickening in human cardiac allografts was not fully characterized.
Case Report (n=1)
Demonstrates that intimal thickening in cardiac allografts can involve cells of both donor and host origin.
Majority donor cells predominate in allograft intimal thickening; leaves open host cell contributions to chronic transplant vasculopathy.
The origin of the cells present in the arterial intimal thickening in a human cardiac allograft surviving for two years was determined by fluorescent antiserums directed against the donor and host HL-A antigens. The majority of the cells in the thickened intima were of donor tissue type, but in one vessel an appreciable number of cells from the host were identified in the thickened arterial intima.
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Kennedy et al. (1971) conducted a case report in Cardiac-Allograft Arteriosclerosis (n=1). Fluorescent antiserums directed against donor and host HL-A antigens was evaluated on Origin of cells in arterial intimal thickening. Analysis of a human cardiac allograft surviving for two years revealed that while most cells in the thickened intima were of donor origin, an appreciable number of host cells were also identified.
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