Key result
Human cardiac allografts exhibit extensive immunoglobulin deposits versus donor hearts, indicating strong humoral rejection.
Why the study?
Does human cardiac allograft rejection involve humoral immune responses characterized by immunoglobulin deposition?
Population
14 human cardiac allografts, 8 original hearts from recipients, biopsies of 6 donor hearts taken before…
Comparison
Direct and indirect immunofluorescence studies vs Original hearts from recipients and biopsies of…
Design
Case_series
Authors
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Supports humoral involvement in cardiac allograft rejection; hypothesis-generating and should not yet change practice.
Observational (n=17)
Does human cardiac allograft rejection involve humoral immune responses characterized by immunoglobulin deposition?
The study provides evidence that human cardiac allografts provoke a strong humoral rejection response linked to obliterative vascular lesions.
Rossen et al. (1971) conducted an observational in Cardiac allograft recipients (n=17). Cardiac allograft vs. Original hearts and donor hearts before transplantation was evaluated on Immunoglobulin deposition in cardiac tissues. Human cardiac allografts exhibited extensive immunoglobulin deposits in the sarcolemma and coronary arteries compared to original or donor hearts, indicating a strong humoral rejection response.
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