Key result
Dahl salt-sensitive rats exhibit ~100% higher urinary calcium excretion than salt-resistant controls.
Why the study?
Abnormal calcium homeostasis has been reported in essential hypertension and spontaneously hypertensive rats, but its characteristics in Dahl hypertensive rats were not fully understood.
Absolute Event Rate: 0.48% vs 0.24%
p-value: p=<0.01
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May extend Ca dysregulation observations to Dahl salt-sensitive rats; leaves open human translation and mechanisms.
Umemura et al. (1986) studied Hypertension. Dahl salt sensitive (S) strain vs. Dahl salt resistant (R) strain was evaluated on Urinary calcium excretion at 7 weeks (mg/mg creatinine) (p=<0.01). Dahl salt-sensitive rats exhibited higher urinary calcium excretion compared to salt-resistant rats at 7 weeks (0.48 vs 0.24 mg/mg creatinine, P<0.01) and decreased renal adenylate cyclase response.
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