Key result
Alpha-1 anti-trypsin was identified as a naturally occurring competitive inhibitor of renin in human plasma, whereas other proteinase inhibitors had no inhibitory effect.
Alpha-1 anti-trypsin is a naturally occurring competitive inhibitor of renin, providing basic science insights into the regulation of the renin-angiotensin system.
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Alpha-1 antitrypsin may modulate renin in vitro; leaves open its physiological role and any clinical relevance.
A naturally occurring competitive inhibitor of pig kidney renin has been identified in human plasma. The inhibitor was shown to be alpha-1 anti-trypsin and the effect in vitro on the renin activity was examined. The slope in the Hill plot is compatible with the assumption of one-site competitive inhibition. Other proteinase inhibitors, such as alpha-2-macroglobulin and C1 inactivator, however, have no inhibitory effect on the renin-angiotensinogen reaction.
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Scharpé et al. (1976) studied this question. alpha-1 anti-trypsin vs. alpha-2-macroglobulin and C1 inactivator was evaluated on renin activity. Alpha-1 anti-trypsin was identified as a naturally occurring competitive inhibitor of renin in human plasma, whereas other proteinase inhibitors had no inhibitory effect.
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