New insights into bicuspid aortic valve disease: the elongated anterior mitral leaflet
Key result
BAV is linked to ~20% longer anterior mitral leaflets compared to tricuspid aortic valves.
- P<0.001
- n=104
Why the study?
The bicuspid aortic valve is associated with various cardiovascular malformations, but systematic examination of mitral valve morphology in BAV patients was lacking.
Is the presence of a bicuspid aortic valve associated with elongation of the anterior mitral leaflet compared to a tricuspid aortic valve or healthy subjects?
Comparison
BAV patients vs TAV patients and healthy subjects
Design
Observational cross-sectional study using transthoracic echocardiography
Authors
Discussion
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Member takes
Implication
AML elongation associated with BAV, especially with AI; leaves open whether mitral assessment should modify BAV surgical planning.
Study Design
Type
Observational (n=104)
Structured PICO
Is the presence of a bicuspid aortic valve associated with elongation of the anterior mitral leaflet compared to a tricuspid aortic valve or healthy subjects?
P
Population
104 subjects comprising 44 operated patients with BAV, 40 with TAV, and 20 healthy controls, evaluated for mitral valve morphology.
E
Exposure
Presence of bicuspid aortic valve (BAV)
C
Comparator
Tricuspid aortic valve (TAV) and healthy normal subjects
O
Outcome
Anterior mitral leaflet (AML) length measured by transthoracic echocardiographysurrogate
Main Result
Absolute Event Rate: 33.2% vs 27.7%
p-value: p=<0.001
Bicuspid aortic valve disease is associated with significant elongation of the anterior mitral leaflet, particularly in patients with concomitant aortic regurgitation, suggesting cardiovascular alterations extend beyond the aortic root.
Cite This Study
Charitos et al. (2012) conducted an observational in Bicuspid aortic valve disease (n=104). Bicuspid aortic valve vs. Tricuspid aortic valve and healthy subjects was evaluated on Anterior mitral leaflet (AML) length (p=<0.001). Patients with a bicuspid aortic valve had significantly elongated anterior mitral leaflets compared to those with a tricuspid aortic valve and normal subjects (33.2 vs 27.7 vs 27.0 mm; P<0.001).