Key result
MDM2/CPM amplification was present in 91% of mixed well-differentiated and pleomorphic liposarcomas, suggesting a subset of pleomorphic liposarcomas may arise through tumor progression.
Population
12 patients with liposarcomas with mixed well-differentiated and pleomorphic features, mean age 59 years.
Design
Case_series
Follow-up
mean 44 months (for patients with >12 months follow-up)
Authors
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May refine liposarcoma subtyping; leaves open whether MDM2 testing informs prognosis or management.
Observational (n=12)
The presence of MDM2/CPM amplification in the pleomorphic component of mixed well-differentiated/pleomorphic liposarcomas suggests these tumors may arise through progression of well-differentiated liposarcoma.
Boland et al. (2010) conducted an observational in Liposarcomas with mixed well-differentiated and pleomorphic features (n=12). Pleomorphic liposarcoma arising in well-differentiated liposarcoma was evaluated on MDM2/CPM amplification. MDM2/CPM amplification was present in 91% of mixed well-differentiated and pleomorphic liposarcomas, suggesting a subset of pleomorphic liposarcomas may arise through tumor progression.
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