November 12, 2013Cancer Cytopathology
Dedifferentiated liposarcoma and pleomorphic liposarcoma
Key result
MDM2 and CDK4 expression reliably distinguishes DDLPS from PLPS despite overlapping cytologic features.
- n=38
Why the study?
The cytomorphologic features of dedifferentiated liposarcoma and pleomorphic liposarcoma and the utility of ancillary studies have not been systemically analyzed.
What are the cytomorphologic differences and utility of MDM2/CDK4 immunohistochemistry in distinguishing dedifferentiated liposarcoma from pleomorphic liposarcoma?
Comparison
Cytologic features and immunohistochemistry for MDM2 and CDK4 in DDLPS versus PLPS
Design
Retrospective observational study
Authors
Discussion
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Member takes
Implication
MDM2/CDK4 coexpression may aid cytologic distinction of DDLPS from PLPS; hypothesis-generating and requires prospective validation.
Study Design
Type
Observational (n=38)
Structured PICO
What are the cytomorphologic differences and utility of MDM2/CDK4 immunohistochemistry in distinguishing dedifferentiated liposarcoma from pleomorphic liposarcoma?
P
Population
38 histologically confirmed cases of dedifferentiated liposarcoma (n=25) and pleomorphic liposarcoma (n=13) evaluated retrospectively.
E
Exposure
Cytologic evaluation and immunohistochemistry for MDM2 and CDK4
C
Comparator
Comparison between DDLPS and PLPS
O
Outcome
Cytomorphologic features and expression of MDM2 and CDK4surrogate
Coexpression of MDM2 and CDK4 reliably distinguishes dedifferentiated liposarcoma from pleomorphic liposarcoma, despite overlapping cytologic features.
Cite This Study
Mariño‐Enríquez et al. (2013) conducted an observational in Dedifferentiated liposarcoma and pleomorphic liposarcoma (n=38). Dedifferentiated liposarcoma vs. Pleomorphic liposarcoma was evaluated on Cytomorphologic features and MDM2/CDK4 expression. Dedifferentiated liposarcoma and pleomorphic liposarcoma exhibit overlapping cytologic features, but expression of MDM2 (96%) and CDK4 (80%) distinguishes DDLPS from PLPS (0% coexpression).