Key result
Hypokalemia in digitalized patients linked to 100% ventricular arrhythmia rate during cardioversion vs 11% normally.
Why the study?
The safety and outcomes of direct current cardioversion in digitalized patients with mitral valve disease and atrial arrhythmias, particularly regarding ventricular arrhythmias and electrolyte imbalance, were not well characterized.
Does hypokalemia increase the risk of postcardioversion ventricular arrhythmias in digitalized patients with mitral valve disease undergoing direct current cardioversion?
Observational (n=23)
Does hypokalemia increase the risk of postcardioversion ventricular arrhythmias in digitalized patients with mitral valve disease undergoing direct current cardioversion?
Absolute Event Rate: 100% vs 11.1%
p-value: p=<0.001
Hypokalemia significantly increases the risk of ventricular arrhythmias following direct current cardioversion in digitalized patients, highlighting the need for precardioversion potassium correction.
Hypokalemia was associated with universal postcardioversion ventricular arrhythmias in digitalized patients; this Level 5 observation leaves open whether repletion reduces risk.
Thirty-two elective direct current cardioversions were performed in 23 digitalized patients with atrial fibrillation or flutter or both and predominant mitral stenosis who had undergone prior mitral commissurotomy. The immediate success rate was 94%, and 78% of the patients stayed in normal rhythm for at least four weeks after cardioversion. Postcardioversion ventricular arrhythmias occurred in 100% of group 1 patients with hypokalemia and in only 11.1% of group 2 patients without electrolyte imbalance, a significant difference (P<0.001). Congestive heart failure and long-term diuretic therapy, particularly with orally administered diuretics, were important factors predisposing to electrolyte imbalance. If hypokalemia is recognized and treated in the precardioversion period, maintenance digitalis therapy may be continued and cardioversion performed without increased risk of ventricular arrhythmias.
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Gurdarshan S. Thind (1969) conducted an observational in Atrial fibrillation or flutter with mitral valve disease (n=23). Hypokalemia vs. Without electrolyte imbalance was evaluated on Postcardioversion ventricular arrhythmias (p=<0.001). Hypokalemia in digitalized patients undergoing direct current cardioversion was associated with a higher rate of ventricular arrhythmias compared to no electrolyte imbalance (100% vs 11.1%, P<0.001).
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