Key result
Dual-RV lead CRT shows feasibility for severe right ventricular heart failure in repaired tetralogy of Fallot.
Why the study?
Progressive right ventricular dysfunction causing morbidity and mortality is common in adults with repaired tetralogy of Fallot and management of RV heart failure can be refractory to medical therapies.
Case Report (n=2)
Standard cardiac resynchronization therapy with a second right ventricular lead is proposed as a therapeutic strategy for severe right ventricular heart failure in patients with repaired tetralogy of Fallot.
Although early surgical repair for tetralogy of Fallot (rTOF) has significantly improved clinical outcomes and long-term survival,1 progressive right ventricle (RV) dysfunction driving morbidity and mortality is often observed in adults with rTOF.2 Management of RV heart failure is occasionally refractory to even appropriate medical therapies.3 RV mechanical dyssynchrony that is commonly observed in rTOF patients with right bundle branch block (RBBB) promotes depressed contractility and remodeling, and it is proposed as a desirable therapeutic target.
No takes yet. Share an insight, caveat, or question.
Irie et al. (2015) conducted a case report in Severe right ventricular heart failure in repaired tetralogy of Fallot (n=2). Standard cardiac resynchronization therapy with a second right ventricular lead was evaluated. Standard cardiac resynchronization therapy with a second right ventricular lead was utilized for severe right ventricular heart failure in 2 patients with repaired tetralogy of Fallot.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: