Key result
Pediatric heart transplantation is linked to ~5-fold greater orthostatic systolic blood pressure drops versus controls.
Why the study?
Short-term variability in blood pressure and heart rate after heart transplantation in children and the extent of cardiac reinnervation remain unclear.
How does heart transplantation affect short-term variability in blood pressure and heart rate in children compared to normal controls?
Comparison
Heart transplant recipients vs normal controls
Design
Observational cross-sectional study
Authors
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Exaggerated orthostatic BP drops and reduced HR variability in pediatric transplant recipients merit monitoring; leaves open extent of sympathetic reinnervation.
Observational (n=27)
How does heart transplantation affect short-term variability in blood pressure and heart rate in children compared to normal controls?
A proportion of children who have received heart transplantation demonstrate delayed reinnervation of the heart, likely involving sympathetic effectors, which becomes apparent more than 44 months post-transplant.
Constant et al. (1995) conducted an observational in Heart transplantation (n=27). Heart transplantation vs. Normal control children was evaluated on Short-term variability in blood pressure and heart rate. Children with heart transplants exhibited greatly reduced heart rate variability and an early active standing drop in systolic blood pressure 4-6 times as great as normal controls.
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