Key result
Inoculation with a very virulent Marek's disease virus strain induced high incidences of non-suppurative meningoencephalomyelitis and necrotizing lymphomatous CNS lesions in resistant chickens.
Population
Marek's disease-resistant chickens
Design
Preclinical
Authors
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vvMDV drives prominent CNS lesions in resistant chickens; leaves open mechanisms of neurovirulence and resistance.
In Marek's disease-resistant chickens, a very virulent strain of Marek's disease virus induces high incidences of necrotizing and non-necrotizing CNS lesions, likely driven by necrotizing vasculitis and ischemic damage.
Cho et al. (1998) studied Marek's disease virus infection. Inoculation with very virulent Marek's disease virus strain (vvMDV), Md/5 was evaluated on Histological lesions of central nervous system (CNS). Inoculation with a very virulent Marek's disease virus strain induced high incidences of non-suppurative meningoencephalomyelitis and necrotizing lymphomatous CNS lesions in resistant chickens.
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